货号:AB3572P
品牌:Merck Millipore
规格:50Ug
目录价:¥6127.00
市场价格:¥5207.95
会员价格:¥4901.60
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Description:
Anti-Organic Anion Transporting Polypeptide 2 Antibody, C-terminus, intracellular
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Promotional Text:
Special Shipping Offer on Antibodies100% Performance Guaranteed
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Trade Name:
Chemicon (Millipore)
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Specificity:
Recognizes rat Organic Ion Transporter 2 Polypeptide 2.
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Epitope:
C-terminus, intracellular
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Immunogen:
A 12 amino acid peptide sequence near the cytoplasmic, C-terminus of rat OATP2. The immunogen shows no significant sequence similarity to other OATPs or other proteins.
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Background Information:
Organic Anion Transporting Polypeptide 2 is an integral membrane protein that mediates the sodium-independent transport of organic ions, cardiac glycosides and thyroid hormones. Oatp2 is highly expressed in brain, liver, and kidney but not expressed in heart, spleen, lung, skeletal muscle, or testis.
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Species Reactivity:
Rat
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Application Notes:
Western blot: 1-10 μg/mL using ECL. Rat OATP2 is approximately 75 kD in brain and liver (Noe et al. 1997). ELISA: 0.5-1.0 μg/mL using 1 μg/mL control peptide per well. Optimal working dilutions must be determined by the end user.
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Presentation:
Affinity purified immunoglobulin. Liquid in PBS, containing 0.1% BSA.
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Storage Conditions:
Maintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.
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UniProt Number:
Q9Y6L6
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Entrez Gene Number:
NM_006446.3
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Gene Symbol:
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SLCO1B1
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LST1
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LST-1
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OATP2
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OATPC
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OATP1B1
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SLC21A6
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MGC133282
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OATP-C
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Alternate Names:
oatp2; OATP-B1; Brain digoxin carrier protein
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
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ELISA
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Western Blotting
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UniProt Summary:
FUNCTION: SwissProt: Q9Y6L6 # Mediates the Na(+)-independent transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver.SIZE: 691 amino acids; 76449 Da SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane protein. Note=Detected in basolateral membranes of hepatocytes.TISSUE SPECIFICITY: Highly expressed in liver. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.SIMILARITY: SwissProt: Q9Y6L6 ## Belongs to the organo anion transporter (TC 2.A.60) family.
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Brand Family:
Chemicon
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Product Name:
Anti-Organic Anion Transporting Polypeptide 2 Antibody, C-terminus, intracellular
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Concentration:
1.0 mg/mL
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Antibody Type:
Polyclonal Antibody
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Qty/Pk:
50 µg
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Format:
Affinity Purified
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Host:
Rabbit
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