货号：AB3637

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DEDAF Antibody | AB3637 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. DEDAF (DED Associated Factor) is expressed in multiple tissues and cell lines. DEDAF is identical to the transcriptional repressor RYBP. DEDAF interacts with FADD and augments the formation of CD95/FADD/Caspase-8 complexes at the cell membrane. DEDAF also interacts with DEDD (DED-containing DNA binding) protein in the nucleus, which indicates its involvement in the regulation of both cytoplasmic and nuclear events of apoptosis. View All» Immunogen: Rabbit anti-DEDAF polyclonal antibody was raised against a synthetic peptide corresponding to amino acids 215 to 228 of human-DEDAF. This sequence is identical to the mouse sequence. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 0.5-1 μg/mL. A549 or HepG2 cell lysate can be used as a positive control and a 32 kDa band should be detected. Optimal working dilutions must be determined by end user. View All» Presentation: Purified IgG by immunoaffinity chromatography. Liquid in PBS containing 0.02% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: Q8N488 View All» Entrez Gene Number: NM_012234.4 View All» Gene Symbol:
  • RYBP

  • DEDAF

  • YEAF1

  • AAP1

  • APAP-1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: Q8N488 # May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. In tumor cell lines, may induce apoptosis.SIZE: 228 amino acids; 24822 Da SUBUNIT: Interacts with CBX2, YAF2, RING1 and RNF2 (By similarity). Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and E4TF1B. Together with E4TF1B and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Primarily found in the nucleus.TISSUE SPECIFICITY: Widely expressed with highest levels in lymphoid tissues and placenta.SIMILARITY: SwissProt: Q8N488 ## Contains 1 RanBP2-type zinc finger. View All» Brand Family: Chemicon View All» Product Name: Anti-DEDAF Antibody | AB3637 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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