货号：AB3639

品牌：Merck Millipore

规格：100Ug

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Endonuclease G Antibody | AB3639 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Endonuclease G (EndoG), a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. EndoG is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD (1,2). View All» Immunogen: Synthetic peptide corresponding to amino acids 55 to 70 of human EndoG (GGPRGPGELAKYGLP). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blotting (1-2μg/mL) Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. View All» Storage Conditions: Maintain at 2-8ºC for 12 months. View All» UniProt Number: Q14249 View All» Entrez Gene Number: NM_004435.2 View All» Gene Symbol:
  • ENDOG

  • FLJ27463

  • EC 3.1.30.-
    View All» Alternate Names: EndoG View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. View All» UniProt Summary: FUNCTION: SwissProt: Q14249 # Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).COFACTOR: Manganese or magnesium (By similarity).SIZE: 297 amino acids; 32646 Da SUBUNIT: Homodimer (By similarity).SUBCELLULAR LOCATION: Mitochondrion.SIMILARITY: SwissProt: Q14249 ## Belongs to the DNA/RNA non-specific endonuclease family. MISCELLANEOUS: The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules (By similarity). View All» Brand Family: Chemicon View All» Product Name: Anti-Endonuclease G Antibody | AB3639 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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