货号：AB3640

品牌：Merck Millipore

规格：

目录价：￥3884.00

市场价格：￥3301.40

会员价格：￥3107.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Caspase 3 Antibody | AB3640 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: AB3640 recognizes a region within the p17 large subunit of Caspase 3. The antibody will detect both pro- and large subunit forms of the protein, as well as partially processed intermediates in apoptotically induced cells. View All» Molecular Weight: 32-35 kDa pro-form and 17 kDa large subunit View All» Epitope: a.a. 104-117 View All» Immunogen: Peptide corresponding to a.a. 104-117 of human Caspase 3 View All» Background Information: Caspase-3 is the most extensively studied apoptotic protein. Caspase-3 is synthesized as an inactive proenzyme (~32-35 kDa) that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another upstream protease. The processed form of caspase-3 consists of large (17 kDa) and small (12 kDa) subunits which associate to form an active enzyme. The active caspase-3 proteolytically cleaves and activates other caspases, as well as relevant targets in the cells such as PARP and DFF. View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Western Blot: 1:500 - 1:1000 View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS, pH 7.6 and 0.1% sodium azide as a preservative. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquotes for up to 12 months from date of receipt. View All» UniProt Number: P42574 View All» Entrez Gene Number:
  • NM_004346.3

  • NM_032991.2
    View All» Gene Symbol:
    • CASP3

    • apopain

    • procaspase3

    • CPP-32

    • Apopain

    • Yama

    • CASP-3

    • CPP32B

    • SCA-1

    • CPP32

    • EC 3.4.22.56 [Contains: Caspase-3 subunit p17

    • Caspase-3 subunit p12].
      View All» Alternate Names: CPP32; Apopain; Yama protein; SCA-1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. View All» UniProt Summary: FUNCTION: SwissProt: P42574 # Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.SIZE: 277 amino acids; 31608 Da SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.PTM: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.SIMILARITY: SwissProt: P42574 ## Belongs to the peptidase C14 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Caspase 3 Antibody | AB3640 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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