货号：AB3875

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SUMO1 Antibody | AB3875 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human SUMO1 (small ubiquitin-like modifier), also known as Sentrin. SUMO has been shown to bind and regulate mammalian SP-RINGs (such as Mdm2, PIAS, and PML), RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, Drosophila Ttk69, Dorsal, CaMK, yeast Septins, and viral CMV-IE1/2, EBV-BZLF1, HPV/BPV-E1. These bindings implicate SUMO in the stabilization of the target proteins and/or their localization to subcellular complexes. View All» Immunogen: Synthetic peptide corresponding to the N-terminal region of human SUMO1. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:500. (12kDa) ELISA: 1:1000 Immunohistochemistry: 1:50-1:100 Optimal working dilutions must be determined by the end user. View All» Presentation: Immunoglobulin was purified by protein G affinity chromatography and is presented as a liquid in PBS with 0.09% sodium azide. View All» Storage Conditions: Maintain at -20ºC in undiluted aliquots for up to one year from date of receipt. View All» UniProt Number: P63165 View All» Entrez Gene Number:

• NM_001005781.1

• NM_001005782.1

• NM_003352.4
  View All» Gene Symbol:
  • SUMO1

  • Sentrin

  • OFC10

  • UBL1

  • SENP2

  • DAP-1

  • sentrin

  • SMT3H3

  • SMT3

  • PIC1

  • SUMO-1

  • GMP1

  • SMT3C
    View All» Alternate Names: Small Ubiquitin-like Modifier; SMT3C; Sentrin View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. View All» UniProt Summary: FUNCTION: SwissProt: P63165 # Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1- SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.SIZE: 101 amino acids; 11557 Da SUBUNIT: Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Interacts with PARK2. Covalently attached to a number of proteins such as PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52.SUBCELLULAR LOCATION: Nucleus membrane. Nucleus speckle. Cytoplasm.PTM: Cleavage of precursor form by SENP1 or SENP2 is necessary for function.SIMILARITY: SwissProt: P63165 ## Belongs to the ubiquitin family. SUMO subfamily. & Contains 1 ubiquitin-like domain. View All» Brand Family: Chemicon View All» Product Name: Anti-SUMO1 Antibody | AB3875 View All» Concentration: 250 μg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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