货号：AB3889

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Vav-3 Antibody | AB3889 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human Vav3. This antibody detects a band of approximately 98 kDa in Western blot analysis of HeLa cell lysate. Lower molecular weight non-specific bands may be eliminated by using the antibody at a higher dilution. View All» Immunogen: Synthetic peptide corresponding to amino acid residues 566-591 of human Vav3 (Accession # Q9UKW4). View All» Background Information: Vav proteins function as Rho family guanine nucleotide exchange factors (GEFs), binding to the nucleotide-free state of these GTPases. The Rho family of GTPases are a key class of signaling molecules that mediate receptor induced rearrangements of the actin cytoskeleton, activation of kinase cascades and changes in gene transcription. Vav-3 is an exchange factor for RhoA, RhoG and, to a lesser extent, Rac1. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:5,000 - 1:10,000 Optimal working dilutions must be determined by the end user. View All» Control: Western blot positive control: HeLa cell line View All» Presentation: Affinity purified immunoglobulin. Liquid in 0.02M Phosphate Buffer, 0.25M NaCl, with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C for up to 12 months from date of receipt. View All» UniProt Number: Q9UKW4 View All» Entrez Gene Number:

• NM_001079874.1

• NM_006113.4
  View All» Gene Symbol:
  • VAV3

  • FLJ40431
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. View All» UniProt Summary: FUNCTION: SwissProt: Q9UKW4 # Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases.SIZE: 847 amino acids; 97776 Da SUBUNIT: Interacts with the PH domain of APS.SIMILARITY: SwissProt: Q9UKW4 ## Contains 1 CH (calponin-homology) domain. & Contains 1 DH (DBL-homology) domain. & Contains 1 PH domain. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 SH2 domain. & Contains 2 SH3 domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Vav-3 Antibody | AB3889 View All» Concentration: 1.16 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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