货号：AB3890

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DAP12 Antibody | AB3890 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human DAP12. This antibody detects a band of approximately 12 kDa in Western blot analysis of U937 cell lysate. View All» Immunogen: Synthetic peptide corresponding to amino acid residues 89-113 of human DAP12 (Accession # AAD09437). View All» Background Information: Natural killer (NK) cells are lymphocytes that function as a component of innate immunity against intracellular and parasitic pathogens, and possibly tumors. DAP12 is expressed on the surface of NK cells as a disulfide-linked homodimer and contains an immunoreceptor tyrosine based activation motif (ITAM) in its cytoplasmic domain. DAP12 non-covalently associates with members of the killer cell immunoglobulin-like receptor (KIR) family resulting in cellular activation. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1.0 μg/mL Optimal working dilutions must be determined by the end user. View All» Control: Western blot positive control: U937 cell line View All» Presentation: Protein A purified immunoglobulin. Liquid in 0.02M Phosphate Buffer, 0.25M NaCl, with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C for up to 12 months from date of receipt. View All» UniProt Number: O43914 View All» Entrez Gene Number:

• NM_003332.2

• NM_198125.1
  View All» Gene Symbol:
  • TYROBP

  • DAP12

  • PLO-SL

  • KARAP

  • PLOSL
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Two alternative transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described, but their full-length nature has not been deterimined. View All» UniProt Summary: FUNCTION: SwissProt: O43914 # Non-covalently associates with membrane glycoproteins of the killer-cell inhibitory receptor (KIR) family without an ITIM in their cytoplasmic domain. Cross-linking of KIR-TYROBP complexes results in cellular activation.SIZE: 113 amino acids; 12179 Da SUBUNIT: Homodimer; disulfide-linked. Interacts with SIRPB1 and TREM1. Interacts with CLECSF5. Interacts with SIGLEC14.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.PTM: Tyrosine phosphorylated.DISEASE: "SwissProt: O43914 # Defects in TYROBP are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]; also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns."SIMILARITY: SwissProt: O43914 ## Belongs to the TYROBP family. View All» Brand Family: Chemicon View All» Product Name: Anti-DAP12 Antibody | AB3890 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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