货号：AB3902

品牌：Merck Millipore

规格：

目录价：￥2902.00

市场价格：￥2466.70

会员价格：￥2321.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MLH1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Homolog 1 of E. coli MutL protein (MHL1, DNA Mismatch Repair Protein MHL1). View All» Immunogen: Synthetic peptide from human MLH1. ). The antibody recognizes a region between amino acids 700 and the C-terminus (amino acid 756) of human mutL homolog 1. View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:500-1:5,000 Immunohistochemistry: 1:50-1:200 Immunoprecipitation: 1-4 μL Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in Tris-citrate/phosphate, pH 7-8 with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted for up to 6 months after date of receipt. View All» UniProt Number: P40692 View All» Entrez Gene Number: NM_000249.2 View All» Gene Symbol:

• MLH1

• HNPCC

• COCA2

• MGC5172

• HNPCC2

• FCC2

• hMLH1
  View All» Alternate Names: DNA Mismatch Repair Protein MLH1; MytL View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting

  • Immunohistochemistry
    View All» Entrez Gene Summary: This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. View All» UniProt Summary: FUNCTION: SwissProt: P40692 # Involved in the repair of mismatches in DNA.SIZE: 756 amino acids; 84601 Da SUBUNIT: Heterodimer of MLH1 and PMS2 or MLH1 and MLH3. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50- MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with MBD4. Interacts with EXO1.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Colon, lymphocytes, breast, lung, spleen, testis, prostate, thyroid, gall bladder and heart.DISEASE: SwissProt: P40692 # Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2) [MIM:609310]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Clinically, HNPCC is often divided into two subgroups. Type I: hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II: patients have an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term suspected HNPCC or incomplete HNPCC can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. & Defects in MLH1 are a cause of Turcot syndrome [MIM:276300]. Turcot syndrome is an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas. Skin features include sebaceous cysts, hyperpigmented and cafe au lait spots. & Defects in MLH1 are a cause of Muir-Torre syndrome (MTS) [MIM:158320]. MTS is a rare autosomal dominant disorder characterized by sebaceous neoplasms and visceral malignancy. & Defects in MLH1 may contribute to lobular carcinoma in situ (LCIS), a non-invasive neoplastic disease of the breast. & Defects in MLH1 are a cause of susceptibility to endometrial cancer [MIM:608089].SIMILARITY: SwissProt: P40692 ## Belongs to the DNA mismatch repair mutL/hexB family. View All» Brand Family: Chemicon View All» Product Name: Anti-MLH1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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