货号：AB3914

品牌：Merck Millipore

规格：

目录价：￥3393.00

市场价格：￥2884.05

会员价格：￥2714.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SMC3 Antibody | AB3914 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Structural Maintenance of Chromosomes-3 (SMC-3). View All» Immunogen: Synthetic peptide from human SMC-3. View All» Background Information: Structural Maintenance of Chromomosomes-3 (SMC3) protein is involved in chromomosome cohesion during cell cycle and DNA repair. This nuclear protein is a key component of the cohesin complex, which is required for the cohesion of sister chromatids after DNA replication. View All» Species Reactivity:

• Human

• Xenopus
  View All» Application Notes: Western blot: 1:1,000-1:10,000 Immunocytochemistry: 1:200-1:800 Immunoprecipitation: 2-6 μL Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in Tris-citrate/phosphate, pH 7-8 with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted for up to 6 months. View All» UniProt Number: Q9UQE7 View All» Entrez Gene Number: NM_005445.3 View All» Gene Symbol:
  • SMC3

  • bamacan

  • BMH

  • HCAP

  • BAM

  • CDLS3

  • CSPG6

  • SMC3L1

  • Bamacan

  • hCAP
    View All» Alternate Names: Structural Maintanence of Chromosomes 3; Chondroitin Sulfate Proteoglycan 6; Bamacan; hCAP View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. View All» UniProt Summary: FUNCTION: SwissProt: Q9UQE7 # Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis and in chromosome movement.SIZE: 1217 amino acids; 141542 Da SUBUNIT: Interacts with MXI1, MXD3 and MXD4. Interacts with SYCP2. Found in a complex with SMC1A, CDCA5 and RAD21, PDS5A/APRIN and PDS5B/SCC-112 (By similarity). Forms a heterodimer with SMC1A or SMC1B in cohesin complexes. Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Also found in meiosis-specific cohesin complexes. Interacts with NUMA1, and forms a ternary complex with KIF3B and KIFAP3, suggesting a function in tethering the chromosomes to the spindle pole and in chromosome movement.SUBCELLULAR LOCATION: Nucleus. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.DOMAIN: SwissProt: Q9UQE7 The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC1A or SMC1B, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity).PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.DISEASE: SwissProt: Q9UQE7 # Defects in SMC3 are the cause of Cornelia de Lange syndrome type 3 (CDLS3) [MIM:610759]. CDLS is a dominantly inherited multisystem developmental disorder characterized by growth and cognitive retardation, abnormalities of the upper limbs, gastroesophageal dysfunction, cardiac, ophthalmologic and genitourinary anomalies, hirsutism, and characteristic facial features. CDSL3 is a mild form with absence of major structural anomalies typically associated with CDLS. The phenotype in some instances approaches that of apparently non-syndromic mental retardation.SIMILARITY: Belongs to the SMC family. SMC3 subfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-SMC3 Antibody | AB3914 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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