货号：AB4087

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Protein Phosphatase 2 A/B δ Antibody | AB4087 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes the Bdelta regulatory subunit isotype of protein phosphatase 2A (PP2A). View All» Immunogen: Synthetic peptide conjugated to KLH derived from the N-terminus of PP2A/B delta. View All» Isotype: IgG View All» Background Information: PP2A is a heterotrimeric phosphatase, composed of A, B and C subunits. The structural A and catalytic C subunits form the constitutive core of the enzyme, which associates with one of a large number of regulatory B subunits. Three families of B subunits have been identified thus far. The prototypical B (or PR55) family of subunits is encoded by three genes, Balpha, Bbeta and Bgamma. The B' (or B56) family consists of at least seven splice variantsderived from five genes. RNA's for the two members of the B'' family, PR72 and PR130, arise by alternative splicing or use of alternate transcription start sites from the same gene. Primary structures as well as functions of B and B' subunits are conserved from yeast to mammals. Bdelta is a novel isoform of the B class of PP2A regulatory subunits. It is widely expressed in rat tissues and appears to be involved in targeting PP2A to the cytosolic compartment. View All» Species Reactivity:

• Bovine

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot Immunofluorescence Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Provided as 0.2μm sterile filtered solution in phosphate buffered saline with 0.08% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q14738 View All» Entrez Gene Number:
  • NM_006245.2

  • NM_180976.1

  • NM_180977.1
    View All» Gene Symbol:
    • PPP2R5D

    • MGC8949

    • MGC2134

    • OTTHUMP00000039821

    • B56D
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunofluorescence

      • Western Blotting
        View All» Entrez Gene Summary: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. View All» UniProt Summary: FUNCTION: SwissProt: Q14738 # The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.SIZE: 602 amino acids; 69992 Da SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis.TISSUE SPECIFICITY: Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: SwissProt: Q14738 ## Belongs to the phosphatase 2A regulatory subunit B56 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Protein Phosphatase 2 A/B δ Antibody | AB4087 View All» Concentration: 1 mg/Ml View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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