货号：AB4227

品牌：Merck Millipore

规格：200Ug

目录价：￥4239.00

市场价格：￥3603.15

会员价格：￥3391.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Pax5 Antibody | AB4227 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Pax5. View All» Immunogen: Synthetic peptide corresponding to an N-terminal sequence of human Pax5. View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Western blot: 2-5 μg/mL Optimal working dilutions must be determined by end user. View All» Presentation: Peptide affinity purified antibody. Liquid in 0.02M phosphate buffer, 0.25M NaCl, with 0.1% sodium azide as a preservative. View All» Storage Conditions: Maintain at 2-8ºC in undiluted aliquots for up to one year from date of receipt. View All» UniProt Number: Q02548 View All» Entrez Gene Number: NM_016734.1 View All» Gene Symbol:
  • PAX5

  • BSAP
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: Q02548 # May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.SIZE: 391 amino acids; 42149 Da SUBUNIT: Interacts with DAXX (By similarity). Binds DNA as a monomer. Binds TLE4.SUBCELLULAR LOCATION: Nucleus.DEVELOPMENTAL STAGE: Expressed at early B-cell differentiation, in the developing CNS and in adult testis.PTM: O-glycosylated (Probable).DISEASE:SwissProt: Q02548 # A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.SIMILARITY: SwissProt: Q02548 ## Contains 1 paired domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Pax5 Antibody | AB4227 View All» Concentration: 1.08 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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