货号：AB4235

品牌：Merck Millipore

规格：100Ug

目录价：￥7742.00

市场价格：￥6580.70

会员价格：￥6193.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-AMACR Antibody | AB4235 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human AMACR (alpha-methylacyl-CoA racemase). View All» Immunogen: Synthetic human AMACR peptide. View All» Background Information: Prostate-specific antigen (PSA) screening for prostate cancer is now widespread in the United States among men of all ages. However PSA has limited specificity because benign disease, including prostatic enlargement and inflammation, can increase PSA levels. Thus, a more specific prostate cancer markers is needed. One such potential marker is AMACR, an enzyme that is involved in peroxisomal beta-oxidation of dietary branched-chain fatty acids. Recent studies have shown that, compared with expression in normal or benign prostate epithelium, AMACR is consistently overexpressed in prostate cancer epithelium, making it a specific marker for cancer cells within the prostate gland. Furthermore, overexpression of AMACR may increase the risk of prostate cancer because its expression is increased in premalignant lesions (prostatic intraepithelial neoplasia). View All» Species Reactivity: Human View All» Application Notes: Western blot: 1:500 Immunohistochemistry: 1:100 in an ABC method. An incubation period of 30 minutes at room temperature is suggested. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Optimal working dilutions must be determined by end user. View All» Presentation: Peptide affinity purified antibody. Liquid in PBS, with 0.02% sodium azide as a preservative. View All» Storage Conditions: Maintain at 2-8ºC in undiluted aliquots for 3 months or at -20°C for up to one year from date of receipt. Avoid repeated freeze-thaw cycles. View All» UniProt Number: Q9UHK6 View All» Entrez Gene Number:

• NM_014324.4

• NM_203382.1
  View All» Gene Symbol:
  • AMACR

  • RACE

  • EC 5.1.99.4
    View All» Alternate Names: a-methylacyl-CoA racemase; P504S View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: Alpha-methylacyl-CoA racemase is responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers, which are the only stereoisomers that can be degraded via peroxisomal beta-oxidation.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q9UHK6 # Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.SIZE: 382 amino acids; 42360 Da SUBCELLULAR LOCATION: Peroxisome. Mitochondrion.DISEASE: SwissProt: Q9UHK6 # Defects in AMACR are the cause of AMACR deficiency [MIM:604489]. It results in elevated concentrations of pristanic acid. It is associated with a form of adult onset sensory motor neuropathy. & Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4) [MIM:214950]; also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.SIMILARITY: SwissProt: Q9UHK6 ## Belongs to the caiB/baiF CoA-transferase family. View All» Brand Family: Chemicon View All» Product Name: Anti-AMACR Antibody | AB4235 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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