货号：AB4326

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ISL-1 Antibody | AB4326 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes ISL-1. View All» Molecular Weight: ~39 kDa View All» Epitope: Internal region of ISL-1. View All» Immunogen: KLH-conjugated linear peptide corresponding to human ISL-1. View All» Background Information: Islet-1 (ISL-1) is a transcription factor that plays an important role in the embryogenesis of pancreatic islets of Langerhans. It is expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain. In mouse embryos, a deficiency of this gene fail to undergo neural tube motor neuron differentiation. More recently it has been identified as a marker for a cardiac progenitor cell lineage that is capable of differentiating into all 3 major heart cell types: cardiomyocytes, smooth muscle and endothelial cell lineages. View All» Species Reactivity:

• Human

• Mouse

• Horse

• Bovine

• Sheep

• Rat

• Canine
  View All» Species Reactivity Note: Tested to react with human and mouse. Predicted to react with equine, bovine, sheep, rat, canine, and most common vertebrate species based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:300 dilution from a previous lot detected ISL-1 in mouse pancreas tissue. View All» Control: K562 cell lysate View All» Quality Assurance: Evaluated by Western Blot in K562 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected ISL-1 on 10 µg of K562 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P61371 View All» Entrez Gene Number: NP_002193 View All» Gene Symbol:
  • ISL1

  • islet-1

  • Islet-1

  • Isl-1

  • ISL-1
    View All» Alternate Names:
    • ISL LIM homeobox 1

    • ISL1 transcription factor, LIM/homeodomain

    • ISL1 transcription factor, LIM/homeodomain, (islet-1)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: SwissProt: P61371 # Binds to one of the cis-acting domain of the insulin gene enhancer.SIZE: 349 amino acids; 39036 Da SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.SIMILARITY: SwissProt: P61371 ## Contains 1 homeobox DNA-binding domain. & Contains 2 LIM zinc-binding domains. View All» Product Name: Anti-ISL-1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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