货号：AB5060

品牌：Merck Millipore

规格：50UL

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Substance P Receptor Antibody, pain | AB5060 View All» Replaces: AB5800 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Specific for the Substance P Receptor (NK-1). View All» Molecular Weight: 35 kDa View All» Epitope: C terminus View All» Immunogen: Synthetic peptide that corresponds to a 23 amino acid sequence (385-407) of the COOH terminus of the rat Substance P Receptor (NK-1). View All» Background Information: Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapses. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs. View All» Species Reactivity:

• Guinea Pig

• Mouse

• Rat
  View All» Species Reactivity Note: Rat, mouse and guinea pig. View All» Application Notes: Immunohistochemistry: A previous lot was used at 1:100-1:1,000 dilution. Western Blot Analysis:A previous lot was used at 1:500 dilution.Optimal working dilutions must be determined by the end user. View All» Control: Spinal Cord, brain membrane lysate View All» Quality Assurance: Evaluated by western blot on Mouse brain membrane lysates.Western Blot Analysis: 1:500 dilution of this antibody detected NK-1R on 10 μg of Mouse brain membrane lysates. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum in buffer containing liquid with no preservatives. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: P20366 View All» Entrez Gene Number: NM_003182.1 View All» Gene Symbol:
  • TAC1

  • NK2

  • NKA

  • NKNA

  • Hs.2563

  • PPT

  • TAC2
    View All» Alternate Names: NK-1 Receptor View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunofluorescence

    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P20366 # Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.SIZE: 129 amino acids; 15003 Da SUBCELLULAR LOCATION: Secreted.SIMILARITY: SwissProt: P20366 ## Belongs to the tachykinin family. View All» Brand Family: Chemicon View All» Product Name: Anti-Substance P Receptor Antibody, pain | AB5060 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
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