货号:AB5122
品牌:Merck Millipore
规格:50Ug
目录价:¥5666.00
市场价格:¥4816.10
会员价格:¥4532.80
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Description:
Anti-Adrenergic Receptor Antibody, β 3 | AB5122
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Promotional Text:
Special Shipping Offer on Antibodies100% Performance Guaranteed
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Trade Name:
Chemicon (Millipore)
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Specificity:
Human beta 3 adrenergic receptor (B3AR) is a member of the G-protein coupled receptor superfamily. They typically contain 7 transmembrane domains (Barak et al., 1995) Human B3AR is 408 aa membrane protein (Emorine et al., 1989; Grannenman et al., 1992; Van Spronsen et al., 1993; Lelias et al., 1993).
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Immunogen:
A 19 aa sequence at the C-terminus of the human B3AR, splce variant 3 (Emorine et al., 1989; Grannenman et al., 1992; Van Spronsen et al., 1993; Lelias et al., 1993). Control peptide is available under catalog number AG388.
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Species Reactivity:
Human
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Application Notes:
Western blot: 1-10 μg/mL using Chemiluminescence technique ELISA: 1:10,000 - 100,000 Immunohistochemistry: 2-20 μg in formaldehyde fixed tissue. Optimal working dilutions must be determined by end user.
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Presentation:
Affinity Purified immunoglobulin. Liquid in PBS containing 0.1% BSA
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Storage Conditions:
Maintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
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UniProt Number:
P13945
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Entrez Gene Number:
NM_000025.1
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Gene Symbol:
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ADRB3
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ADRB3R
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B3AR
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BETA3AR
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
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ELISA
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Immunohistochemistry
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Western Blotting
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Entrez Gene Summary:
The ADRB3 gene product, beta-3-adrenergic receptor, is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Beta adrenergic receptors are involved in the epenephrine and norepinephrine-induced activation of adenylate cyclase through the action of G proteins.
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UniProt Summary:
FUNCTION: SwissProt: P13945 # Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.SIZE: 408 amino acids; 43519 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed mainly in adipose tissues.SIMILARITY: SwissProt: P13945 ## Belongs to the G-protein coupled receptor 1 family.
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Brand Family:
Chemicon
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Product Name:
Anti-Adrenergic Receptor Antibody, β 3 | AB5122
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Concentration:
1 mg/mL
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Antibody Type:
Polyclonal Antibody
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Qty/Pk:
50 µg
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Format:
Affinity Purified
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Host:
Rabbit
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