货号：AB5128

品牌：Merck Millipore

规格：50Ug

目录价：￥5820.00

市场价格：￥4947.00

会员价格：￥4656.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Melanocortin Receptor-2 Antibody | AB5128 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Immunogen: A 17 aa peptide (designated MCR21) from the 4th cytoplasmic domain of mouse MC2-R. View All» Background Information: Mouse Melanocortin receptor 2 (MC2-R or ACTH-R) is a 297 aa transmembrane protein belonging to the family of G-Protein coupled receptors. It is a receptor for ACTH. It is found in melanocyte and corticoadrenal tissues. Defects in insensitivity or resistance to ACTH and characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1-10 μg/mL using Chemiluminescence technique ELISA: 1:10,000 - 100,000 Optimal working dilutions must be determined by end user. View All» Presentation: Affinity Purified 1mg/mL solution in PBS, with 0.1% BSA. View All» Storage Conditions: Can be refrigerated at 2-8°C in undiluted aliquots for short term use. Maintain frozen at -20°C in undiluted aliquots for up to 12 months. View All» UniProt Number: Q01718 View All» Entrez Gene Number: NM_000529.2 View All» Gene Symbol:
  • MC2R

  • ACTH-R

  • ACTHR

  • MGC125798

  • MC2-R
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting
      View All» Entrez Gene Summary: MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. View All» UniProt Summary: FUNCTION: SwissProt: Q01718 # Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.SIZE: 297 amino acids; 33927 Da SUBUNIT: Interacts with FALP/MRAP.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Melanocytes and corticoadrenal tissue.DISEASE: SwissProt: Q01718 # Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.SIMILARITY: SwissProt: Q01718 ## Belongs to the G-protein coupled receptor 1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Melanocortin Receptor-2 Antibody | AB5128 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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