货号：AB5166-200UL

品牌：Merck Millipore

规格：1EA

目录价：￥8785.75

市场价格：￥7467.89

会员价格：￥7028.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Muscarinic Acetylcholine Receptor m2 Antibody | AB5166-200UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes a full-length m2 protein. It has exhibited no cross reactivity with other muscarinic proteins tested so far. SPECIES REACTIVITIES: In Chimpanzee and gorilla the immunogen sequence is 100% identical. Orangutan (130/132), pig (122/132), and dog (122/132). Other species have not been tested. View All» Immunogen: GST fusion protein (Rybin, 2000) and part of i3 intercellular loop of human m2 muscarinic acetylcholine receptor (amino acids 225-356) (Accession P08172). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Immunohistochemistry on rat brain sections. Western blot: 1:200 using ECL on rat brain membranes. Immunoprecipitation (Vorobiov, 2000; Lee, 2000) Dilutions should be made using a carrier protein such as BSA (1-3%) Optimal working dilutions must be determined by the end user. View All» Control: CONTROL ANTIGEN: Included free of charge with the antibody is 50 μg of control antigen (lyophilized powder in phosphate buffered saline, pH 7.4, containing 5% sucrose and 0.025% sodium azide). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For positive control, in Western blot using 50 ng of protein per lane. For negative control, preincubate 5-7 μg of fusion protein with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P08172 View All» Entrez Gene Number:
  • NM_000739.2

  • NM_001006626.1

  • NM_001006627.1

  • NM_001006628.1

  • NM_001006629.1

  • NM_001006630.1

  • NM_001006631.1

  • NM_001006632.1
    View All» Gene Symbol:
    • CHRM2

    • MGC120006

    • FLJ43243

    • MGC120007

    • HM2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P08172 # The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.SIZE: 466 amino acids; 51715 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.SIMILARITY: SwissProt: P08172 ## Belongs to the G-protein coupled receptor 1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Muscarinic Acetylcholine Receptor m2 Antibody | AB5166-200UL View All» Concentration: 60 μg/200 μL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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