货号：AB5372

品牌：Merck Millipore

规格：50UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Trk B Antibody, pain, a.a. 54-67 rTrkB | AB5372 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: TrkB. The sequence used for the immunogen was chosen to avoid cross reactivity with trkA or trkC. View All» Epitope: a.a. 54-67 rtrkB View All» Immunogen: A synthetic peptide from rat trkB View All» Species Reactivity:

• Human

• Rat
  View All» Application Notes: Immunohistochemistry: 1:2,000-1:3,000. The antibody reacts well with tissue from the rat spinal cord. Immunoblotting: 1:1,000-1:1,500 on rat membrane preparations. The antibody should beevaluated for use in Western blot by the end user. Its utility will be dependant on the level ofthe protein expressed in the tissues or cells being tested.Optimal working dilutions must be determined by end user. View All» Presentation: Rabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue. View All» Storage Conditions: Maintain lyophilized material at -20°C to -70°C for up to 6 months after date of receipt. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q16620 View All» Entrez Gene Number:
  • NM_001007097.1

  • NM_001018064.1

  • NM_001018065.1

  • NM_001018066.1

  • NM_006180.3
    View All» Gene Symbol:
    • NTRK2

    • Trk-B

    • GP145-TrkB

    • TRKB

    • EC 2.7.10.1
      View All» Alternate Names: BDNF/NT-3 Growth Factors Receptor; Tyrosine Kinase Receptor B View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: Q16620 # Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC- gamma-1.SIZE: 822 amino acids; 91999 Da SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Isoform TrkB is widely expressed, mainly in the nervous tissue. In the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in brain.PTM: Ligand-mediated auto-phosphorylation.SIMILARITY: SwissProt: Q16620 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 2 LRR (leucine-rich) repeats. & Contains 1 protein kinase domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Trk B Antibody, pain, a.a. 54-67 rTrkB | AB5372 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://www.16ao.com/thread-153979.htm
        © Merck Millipore代理AB5372 Anti-Trk B Antibody, pain, a.a. 54-67 rTrkB;store at -20℃，产品报价联系微信jinshanbio