货号：AB5388

品牌：Merck Millipore

规格：50UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Synphilin-1 Antibody, a.a. 829-847 | AB5388 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Synphilin-1. Immunohistochemical analysis of human brain indicates a high level of specificity. Peptide sequence used shows 88% sequence homology with mouse synphilin-1 but mouse has not been tested for reactivity. View All» Epitope: a.a. 829-847 View All» Immunogen: A synthetic peptide from human synphilin-1 (amino acids 829-847). View All» Species Reactivity:

• Human

• Rat
  View All» Application Notes: Immunohistochemistry: 1:1,000-1:2,000. Note: The antibody has also been used successfully for Western blot but results may vary from lab to lab. The usefulness of the antibody for Western blot must be determined by each individual laboratory. Optimal working dilutions must be determined by end user. View All» Presentation: Rabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue. View All» Storage Conditions: Maintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9Y6H5 View All» Entrez Gene Number: NM_005460.2 View All» Gene Symbol:
  • SNCAIP

  • MGC39814

  • synphilin-1

  • SYPH1

  • Synphilin-1
    View All» Alternate Names: Alpha-Synuclein Interacting Protein View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» Entrez Gene Summary: This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but their full-length nature has yet to be determined. View All» UniProt Summary: SIZE: 919 amino acids; 100381 Da SUBUNIT: Associates with SNCA, RNF19A AND PARK2.TISSUE SPECIFICITY: Widely expressed, with highest levels in brain, heart and placenta.PTM: Ubiquitinated; mediated by SIAH1 or RNF19A and leading to its subsequent proteasomal degradation.DISEASE: SwissProt: Q9Y6H5 # Defects in SNCAIP are a cause of Parkinson disease (PD) [MIM:168600]. PD is a complex, multifactorial disorder that typically manifests after the age of 50 years, although early- onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at earlier ages and are associated with atypical clinical features. PD is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.SIMILARITY: SwissProt: Q9Y6H5 ## Contains 6 ANK repeats.MISCELLANEOUS: Constructs encoding portions of SNCA and SNCAIP co- transfected in mammalian cells promote cytosolic inclusions resembling the Lewy bodies of Parkinson disease. Coexpression of SNCA, SNCAIP, and PARK2 result in the formation of Lewy body-like ubiquitin-positive cytosolic inclusions. Familial mutations in PARK2 disrupt the ubiquitination of SNCAIP and the formation of the ubiquitin-positive inclusions. These results provide a molecular basis for the ubiquitination of Lewy body-associated proteins and link PARK2 and SNCA in a common pathogenic mechanism through their interaction with SNCAIP. View All» Brand Family: Chemicon View All» Product Name: Anti-Synphilin-1 Antibody, a.a. 829-847 | AB5388 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Target / Localization: Perisynaptic, synuclein related View All» Format: Serum View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-153998.htm
    © Merck Millipore代理AB5388 Anti-Synphilin-1 Antibody, a.a. 829-847;store at -20℃，产品报价联系微信jinshanbio