货号：AB5394

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GABA B Receptor R2 Antibody | AB5394 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes GABAB-R2 receptor. The antiserum stains nerve fibers and cell bodies in untreated animals. The staining pattern for the immunoreactive cell bodies obtained with the GABAB-R2 receptor antiserum corresponds to the pattern described using in situ hybridization with probes to rat GABAB-R2 receptor mRNA (Durkin et al., 1999). Strong GABAB-R2 receptor immunoreactivity is e.g. demonstrated in the Purkinje cells of the cerebellum, in the cerebral cortex, in the medial habelulae, in the spinal cord and in the brainstem. In individual Purkinje neurons, the immunoreactivity is preferentially observed in the periphery of the cells, most likely corresponding to the plasma membrane, but also in the entire dendritic tree extending into the molecular cell layer of the cerebellum. View All» Immunogen: Synthetic peptide corresponding to the C-terminal amino acids of the rat and human GABAB-R2 receptor protein (Kaupman et al., 1998; White et al., 1998; Jones et al., 1998; Martin et al., 1999). View All» Species Reactivity:

• Rat

• Spider
  View All» Application Notes: Immunohistochemistry: 1:1,000-1:2,000 using a cyanine conjugated secondary antibody. Light 4% PFA fixation recommended. Permeabilization with 0.1-.2% triton in the block only; enzymatic detection can be used however substantially higher primary antibody dilutions will be necessary. Traditional formalin fixation is not recommended. Optimal working dilutions must be determined by the end user. View All» Control: Brain tissue View All» Purification Method: Unpurified View All» Presentation: Guinea pig Serum. Liquid. Contains no preservative. View All» Storage Conditions: Maintain for 6 months at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: O75899 View All» Entrez Gene Number: NM_005458.5 View All» Gene Symbol:
  • GABBR2

  • HRIHFB2099

  • OTTHUMP00000063797

  • GPRC3B

  • GPR51

  • HG20

  • Gb2

  • FLJ36928

  • GABA-B-R2

  • GABABR2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» Entrez Gene Summary: B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: O75899 # Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.SIZE: 941 amino acids; 105821 Da SUBUNIT: Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.TISSUE SPECIFICITY: Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.DOMAIN: SwissProt: O75899 Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1.SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-GABA B Receptor R2 Antibody | AB5394 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μL View All» Format: Serum View All» Host: Guinea Pig View All»
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