金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: CD40 Ligand/TNFSF5 Aliases: CD154; CD40LG; gp39; TNFSF5; TRAP Entrez Gene IDs: 959 (Human); 21947 (Mouse); 84349 (Rat) Background: CD40 Ligand/TNFSF5

The receptor of CD40L is CD40, a type I transmembrane glycoprotein belonging to the TNF receptor family. CD40 is expressed on B lymphocytes, monocytes, dendritic cells, and thymic epithelium. Although all monomeric, dimeric and trimeric forms of soluble CD40L can bind to CD40, the soluble trimeric form of CD40L has the most potent biological activity through oligomerization of cell surface CD40, a common feature of TNF receptor family members. The genetic defect in the hyper-IgM syndrome is due to point mutations or deletions of the gene encoding the CD40L, which prevent CD40L from interacting with CD40. CD40L mediates a range of activities on B cells including induction of activation-associated surface antigen, entry into cell cycle, isotype switching, Ig secretion, and memory generation. CD40-CD40L interaction also plays important roles in monocyte activation and dendritic cell maturation.