金山科研平台，产品价格货期咨询微信：jinshanbio Assay Type:Solid Phase Sandwich ELISA Format:96-well strip plate Assay Length:4.5 hours Sample Type & Volume Required Per Well:Serum (100 µL), EDTA Plasma (100 µL), Heparin Plasma (100 µL) Sensitivity:0.4 pg/mL Assay Range:1 - 64 pg/mL (Serum, Heparin Plasma, EDTA Plasma) Specificity:Natural and recombinant human IL-8 Cross-reactivity: Interference:No significant interference observed with available related molecules. Molecule Information: CXCL8/IL-8 Aliases: GCP1; IL8; LAI; MDNCF; NAP1; NCF; TCF; TSG1 Entrez Gene IDs: 3576 (Human); 396880 (Porcine); 403850 (Canine); 493836 (Feline) Background: CXCL8/IL-8

CXCL8 is a potent chemoattractant for neutrophils. In addition, CXCL8 also has a wide range of other proinflammatory effects. CXCL8 causes degranulation of neutrophil specific granules and azurophilic granules. CXCL8 induces expression of the cell adhesion molecules CD11/CD18 and enhances the adherence of neutrophils to endothelial cells and subendothelial matrix proteins. Besides neutrophils, CXCL8 is also chemotactic for basophils, T cells and eosinophils. CXCL8 has been reported to be a co-mitogen for keratinocytes and was also shown to be an autocrine growth factor for melanoma cells. CXCL8 was also reported to be angiogenic both in vivo and in vitro.