金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: HIF-1 alpha Long Name: Hypoxia-inducible Transcription Factor 1 alpha Aliases: HIF1A Entrez Gene IDs: 3091 (Human); 15251 (Mouse); 29560 (Rat) Background: HIF-1 alpha The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha) is the regulated member of the transcription factor heterodimer HIF-1 alpha/beta. HIF-1 alpha binds to hypoxia-response elements (HREs) in the promoters of many genes involved in the adaptation to an environment of insufficient oxygen or hypoxia. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the broad impact of gene regulation by HIF-1 alpha.