金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: GSK-3 beta Long Name: Glycogen Synthase Kinase 3 beta Aliases: GSK3B Entrez Gene IDs: 2932 (Human); 56637 (Mouse); 84027 (Rat) Background: GSK-3 beta

GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.