金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Autoimmune Regulator/AIRE Aliases: AIRE; APECED; APS1; APSI; PGA1 Entrez Gene IDs: 326 (Human); 11634 (Mouse); 294328 (Rat) Background: Autoimmune Regulator/AIRE Autoimmune Regulator (AIRE) is required for the development of T cell tolerance. It regulates the expression of self-antigens by thymic epithelial cells, and mutations in AIRE are causative of the autoimmune disorder, APECED. AIRE regulates gene transcription through interactions with DNA, histone H3, and the nuclear matrix. It contains one HSD domain, a nuclear localization sequence, one SAND domain, and two PHD zinc finger domains.