R&D Systems代理MAB18301 Mouse IL-6 R alpha MAb (Clone 255820) (100 UG)-试剂-金山科研平台

R&D Systems代理MAB18301 Mouse IL-6 R alpha MAb (Clone 255820) (100 UG)

2025-06-26

货号：MAB18301

品牌：R&D Systems

规格：100ug

目录价：￥3720.00

市场价格：￥2976.00

会员价格：￥2976.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: IL-6 R alpha Long Name: Interleukin 6 Receptor alpha Aliases: CD126; IL6R Entrez Gene IDs: 3570 (Human); 16194 (Mouse) Background: IL-6 Receptor alpha

View IL-6 R alpha IHC images. The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6 R) and a signal-transducing component of 130 kDa (gp 130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. A soluble form of the IL-6 R alpha has been found in the urine of healthy adult humans. This soluble receptor apparently arises from proteolytic cleavage of membrane-bound IL-6 R alpha. No naturally-occurring mRNA encoding a truncated form of the IL-6 R alpha has been reported. Soluble forms of human and murine IL-6 R alphas have been constructed, however, by insertion of termination codons into the regions of the IL-6 R alpha cDNAs encoding the external portions of the receptors and prior to the transmembrane domains. These soluble receptors have been expressed in COS-7 and CHO cells and have been shown to bind to IL-6 in solution and to augment the activity of IL-6 as a result of the binding of the IL-6/IL-6 R alpha complex to membrane-bound gp130.

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