R&D Systems代理MAB2216 Human NF-L MAb (Clone 268014) (100 UG)-试剂-金山科研平台

R&D Systems代理MAB2216 Human NF-L MAb (Clone 268014) (100 UG)

2025-06-28

货号：MAB2216

品牌：R&D Systems

规格：100ug

目录价：￥3720.00

市场价格：￥2976.00

会员价格：￥2976.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: NF-L Long Name: Neurofilament Protein, Light Chain Aliases: CMT2E; NEFL; NF68 Entrez Gene IDs: 4747 (Human) Background: NF-L

View NF-L IHC images. Neurofilaments are intermediate filaments that are major components of the neuronal cytoskeleton. Neurofilaments are composed of three subunits: the heavy subunit (NF-H), medium subunit (NF-M), and light subunit (NF-L). Neurofilaments are trimers that always contain the 68 kDa NF-L and variably contain 125 kDa NF-M and 200 kDa NF-H. The human neurofilament heavy chain is a phosphorylated cytoskeletal intermediate filament protein that is expressed in neurons. The neurofilament medium subunit Human NF-M is a phosphorylated glycoprotein that belongs to the type IV intermediate filament family. NF-L is a 68 kDa light chain cytoskeletal intermediate filament protein that associates with the 125 kDa NF-M and the 200 kDa NF-H to form neurofilaments.

All three neurofilament subunits share a common structure, with globular head, alpha-helical rod, and carboxy terminal side-arm domains. The subunits assemble to form 10 nm neurofilaments. Accumulation of neurofilaments is seen in several human diseases including amyotrophic lateral sclerosis (ALS), Parkinson's disease, Alzheimer's disease, and diabetic neuropathy.

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