金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Siglec-2/CD22 Long Name: Sialic Acid Binding Ig-like Lectin 2 Aliases: BL-CAM; CD22 Entrez Gene IDs: 933 (Human); 12483 (Mouse) Background: Siglec-2 Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.