金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: TGF-beta RIII Long Name: Transforming Growth Factor beta Receptor III Aliases: Betaglycan; BGCAN; TBRIII; TGFBR3 Entrez Gene IDs: 7049 (Human); 21814 (Mouse); 29610 (Rat) Background: TGF-beta Receptors Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta1 and TGF-beta 3 with high affinity and TGF-beta 2 with much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction.