R&D Systems代理MAB2447 Human IGF-II R MAb (Clone 372604) (100 UG)-试剂-金山科研平台

R&D Systems代理MAB2447 Human IGF-II R MAb (Clone 372604) (100 UG)

2025-06-27

货号：MAB2447

品牌：R&D Systems

规格：100ug

目录价：￥3720.00

市场价格：￥2976.00

会员价格：￥2976.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: IGF-II R Long Name: Insulin-like Growth Factor II Receptor Aliases: CD222; CIMPR; IGF2R; M6P-R; MPRI Entrez Gene IDs: 3482 (Human) Background: IGF Receptors

IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The alpha subunit of IGF-I receptor is extracellular while the beta subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGF-I receptor is highly expressed in all cell types and tissues.

IGF-II R is a type I transmembrane glycoprotein that contains a 2,264 amino acid (aa) extracellular region, a 23 aa transmembrane segment segment and a 124 aa cytoplasmic tail. IGF-II R regulates many diverse biological functions that range from intracellular trafficking to the internalization of extracellular factors and modulation of cellular responses. It delivers newly synthesized M6P-tagged lysosomal enzymes from the trans-golgi network to endosomes, and facilitates the clearance of extracellular lysosomal and matrix degrading enzymes by internalization into clathrin-coated vesicles and delivery into endosomes. With respect to IGF-II biology, It would appear that IGF-II R is principally a regulator of local IGF-II levels, targeting IGF-II for destruction in lysosomes.

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