货号：AB5458

品牌：Merck Millipore

规格：50UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neprilysin Antibody (Neutral Endopeptidase, Nep) | AB5458 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Neprilysin (Neutral Endopeptidase, NEP). On western blots of rat kidney extracts the antibody detects a band migrating at approximately 86 kDa corresponding to neprilysin. View All» Molecular Weight: ~86 kDa View All» Immunogen: Rat Neprilysin. View All» Background Information: Human neutral endopeptidase (Neprilysin) is single pass type II integral membrane endopeptidase that functions to activate and degrade biologically active enzymes. Endopeptidase,in general, function to cleave peptide bonds within enzyme sequences, in contrast to exopeptidases that target the end sequence. Neprilysin is part of the peptidase M13 family that acts on polypeptides of less than 30 amino acids with Thermolysin-like specificity for cleave sites. Thermolysin is thought to cleave before amino acids Ile, Met, Phe, Trpm or Val (unless Pro precedes) and after Ala, Asp, His, or Thr. Neprilysin preferentially cleaves polypeptides between hydrophobic residues, particularly with Phe or Tyr at position 1. Neprilysin research has found it important in the degradation of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Research has found it may function in the degradation of atrial natriuretic factor (ANF). Upregulation of ANF functions to regulate homeostatis of water, sodium, potassium and adipose in response to high blood pressure in muscle cells of the heart. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Reacts with Human, Mouse, Rat. Reactivity with other species has not been confirmed. View All» Application Notes: Western Blotting: A previous lot of this antibody was used on Western Blotting.Immunohistochemistry: A previous lot of this antibody was used on Immunohistochemistry.Optimal working dilutions must be determined by the end user. View All» Control: Kidney tissue. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum. Contains no preservative. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: P08473 View All» Entrez Gene Number: NM_000902.3 View All» Gene Symbol:
  • MME

  • EPN

  • NEP

  • MGC126681

  • CD10

  • MGC126707

  • DKFZp686O16152

  • CALLA

  • EC 3.4.24.11
    View All» Alternate Names:
    • neprilysin

    • Neprilysin

    • Enkephalinase

    • enkephalinase

    • atriopeptidase

    • Atriopeptidase

    • Neutral Endopeptidase

    • NEP

    • Endopeptidase 24.11

    • CD10
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. View All» UniProt Summary: FUNCTION: SwissProt: P08473 # Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF).COFACTOR: Binds 1 zinc ion per subunit.SIZE: 750 amino acids; 85514 Da SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.DISEASE: SwissProt: P08473 # Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.SIMILARITY: SwissProt: P08473 ## Belongs to the peptidase M13 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Neprilysin Antibody (Neutral Endopeptidase, Nep) | AB5458 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
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