货号：AB5460-50UL

品牌：Merck Millipore

规格：50UL

目录价：￥4368.12

市场价格：￥3712.90

会员价格：￥3494.50

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Acid Sensitive Ion Channel 2 Antibody, neuronal | AB5460-50UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes ASIC2. The epitope used for the immunogen is specific for ASIC2 and is not similar to any other known protein. The epitope is not specific for ASIC2b (MDEG2) splice variant. SPECIES REACTIVITIES: It is expected that the antibody will also react with mouse due to immunogen sequence homology (100%). Reactivity with other species has not yet been tested. View All» Epitope: neuronal View All» Immunogen: Highly purified peptide corresponding to residues 2-18 of rat or human ASIC2 (Accession Q16515). View All» Species Reactivity:

• Human

• Rat
  View All» Application Notes: Western blotting: 1:200 using ECL on rat brain membranes. Dilutions should be made using a carrier protein such as BSA (1-3%). Optimal working dilutions must be determined by the end user. View All» Control: CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The antigen should be reconstituted with 100 μL of deionized water. For negative control, preincubate 1 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Lyophilized from PBS, pH 7.4, containing 1% BSA, 5% sucrose and 0.025% sodium azide. Reconstitute with 50 μL of sterile distilled water. Centrifuge antibody preparation before use (10,000 x g for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 6 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q16515 View All» Entrez Gene Number:
  • NM_001094.4

  • NM_183377.1
    View All» Gene Symbol:
    • ACCN1

    • degenerin

    • BNC1

    • hBNaC1

    • MDEG

    • BNaC1

    • ACCN

    • ASIC2a

    • BNAC1

    • ASIC2
      View All» Alternate Names: ASIC2; Degenerin; Nueronal Amiloride-sensitive Cation Channel 1; BNaC1; ACCN1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. View All» UniProt Summary: FUNCTION: SwissProt: Q16515 # Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.SIZE: 512 amino acids; 57709 Da SUBUNIT: Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM (By similarity). Interacts with PRKCABP and ACCN3.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes (By similarity).TISSUE SPECIFICITY: Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.SIMILARITY: SwissProt: Q16515 ## Belongs to the amiloride-sensitive sodium channel family. MISCELLANEOUS: Inhibited by anti-inflammatory drugs like salicylic acid (By similarity). Regulated by Zn(2+). View All» Brand Family: Chemicon View All» Product Name: Anti-Acid Sensitive Ion Channel 2 Antibody, neuronal | AB5460-50UL View All» Concentration: 0.3 mg/mL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-158034.htm
      © Merck Millipore代理AB5460-50UL Anti-Acid Sensitive Ion Channel 2 Antibody, neuronal，产品报价联系微信jinshanbio