货号：AB5466

品牌：Merck Millipore

规格：50UL

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Synuclein Antibody, γ | AB5466 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Gamma synuclein. The immunizing peptide was chosen to reduce cross-reactivity of AB6466 with a and b-synuclein. Immunohistochemical and Western blot analysis of human brain indicates a high level of specificity. View All» Immunogen: Peptide corresponding to the amino acids 114-127 of human gamma synuclein protein. View All» Species Reactivity:

• Human

• Rat
  View All» Application Notes: Western blot: 1:500-1:1,000. Immunohistochemistry: 1:1,000 on frozen tissue. Optimal working dilutions must be determined by end user. View All» Presentation: Rabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue. View All» Storage Conditions: Maintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O76070 View All» Entrez Gene Number: NM_003087.1 View All» Gene Symbol:
  • SNCG

  • PERSYN

  • persyn

  • Persyn

  • synoretin

  • BCSG1

  • Synoretin

  • Gamma-synuclein

  • SR

  • PRSN
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: Synuclein-gamma is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development. View All» UniProt Summary: FUNCTION: SwissProt: O76070 # Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).SIZE: 127 amino acids; 13331 Da SUBUNIT: May be a centrosome-associated protein.SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Centrosome. Spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.TISSUE SPECIFICITY: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.PTM: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.DISEASE: SwissProt: O76070 # Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions.SIMILARITY: SwissProt: O76070 ## Belongs to the synuclein family. View All» Brand Family: Chemicon View All» Product Name: Anti-Synuclein Antibody, γ | AB5466 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
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