货号：AB5511

品牌：Merck Millipore

规格：50UL

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Opioid Receptor Antibody, µ, pain | AB5511 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Mu Opioid receptor. View All» Molecular Weight: 45 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide from the C-terminus of rat Mu Opioid receptor. View All» Background Information: Opiates derived from the opium poppy, Papaver somniferum, have been used for millenia for their anti-diarrheal, analgesic and euphoric properties. More recently, endogenous peptides, enkephalins, dynorphins, and endorphins, were found to bind to the same sites as opiate alkaloids. The receptors for the classical opioids are three related GPCRs, δ, κ, and µ (also known as OP1, OP2 and OP3, respectively), that activate Gi/o to reduce intracellular cAMP levels. Although most clinically used opioids function by activation of the µ opioid receptor, agonists of spinal δ opioid receptors have antinociceptive activity that is independent of µ. In addition, activation of δ increases locomotor activity, inhibits gastrointestinal motility, and decreases respiratory frequency (Dhawan et al., 1996). Agonists for δ opioid receptors also exhibit antidepressant-like activity in animal models (Broom et al., 2002). View All» Species Reactivity:

• Human

• Mouse

• Rat

• Primate
  View All» Species Reactivity Note: Human, rat, mouse and primate. Other species have not been tested. View All» Application Notes: Immunohistochemistry: 1:2,500-1:5,000 dilution of a previous lot was used.Western blot: 1:1,000 dilution of a previous lot was used.Immunocytochemistry: 1:2,500-1:5,000 dilution of a previous lot was used.Optimal working dilutions must be determined by the end user. View All» Control: Spinal cord, liver lysate View All» Quality Assurance: Evaluated by Western Blot on Human Liver lysate.Western Blot Analysis: 1:500 dilution of this antibody detected Opioid Receptor on 10 µg of Human Liver lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum in buffer containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: P35372 View All» Entrez Gene Number: NM_000914.2 View All» Gene Symbol:
  • OPRM1

  • MOR

  • MOR-1

  • MOR1

  • OPRM

  • KIAA0403
    View All» Alternate Names:
    • mu opiate receptor

    • opioid receptor, mu 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Immunohistochemistry

      • Western Blotting
        View All» UniProt Summary: FUNCTION: SwissProt: P35372 # Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.SIZE: 400 amino acids; 44779 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.SIMILARITY: SwissProt: P35372 ## Belongs to the G-protein coupled receptor 1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Opioid Receptor Antibody, µ, pain | AB5511 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
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