货号：AB5574-50UL

品牌：Merck Millipore

规格：50UL

目录价：￥4986.69

市场价格：￥4238.69

会员价格：￥3989.35

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TrpC6 Antibody | AB5574-50UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes TRPC6 (Transient Receptor Potential-Like Channel 6, TRP-6). Does not cross react with any other known proteins. SPECIES REACTIVITIES: It is expected that the antibody will also work on human due to sequence conservation (15/16). Other species have not been tested. View All» Immunogen: Peptide corresponding to amino acids 24-38 from mouse TRPC6 (Zhu et al. 1996). Accession Q61143 View All» Species Reactivity: Rat View All» Application Notes: Western blot:1:200-1:400 using ECL on rat brain membranes. Immunohistochemstry on mouse brain sections. Dilutions should be made using a carrier protein such as BSA (1-3%) Addition of 0.1-0.5% Tween-20 to the antibody solution is recommended.Optimal working dilutions must be determined by the end user. View All» Control: CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9Y210 View All» Entrez Gene Number: NM_004621.4 View All» Gene Symbol:

• TRPC6

• FLJ11098

• FSGS2

• TrpC6

• FLJ14863

• TRP6
  View All» Alternate Names: Transient Receptor Potential-Like Channel 6; Trp6 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunohistochemistry

  • Western Blotting
    View All» UniProt Summary: FUNCTION: SwissProt: Q9Y210 # Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.SIZE: 931 amino acids; 106326 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).TISSUE SPECIFICITY: Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.DISEASE: SwissProt: Q9Y210 # Defects in TRPC6 are the cause of focal segmental glomerulosclerosis 2 (FSGS2) [MIM:603965]. FSGS2 is an autosomal dominant disease characterized by increased urinary protein excretion (proteinuria) and decreasing kidney function (nephrotic syndrome). Renal insufficiency often progresses to end-stage renal disease (ESRD) (also known as end-stage renal failure), a highly morbid state requiring either dialysis therapy or kidney transplantation.SIMILARITY: SwissProt: Q9Y210 ## Belongs to the transient receptor family. STrpC subfamily. & Contains 4 ANK repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-TrpC6 Antibody | AB5574-50UL View All» Concentration: 0.8 mg/mL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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