货号：AB5580-200UL

品牌：Merck Millipore

规格：1EA

目录价：￥9102.15

市场价格：￥7736.83

会员价格：￥7281.72

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SCN8A Sodium Channel Antibody | AB5580-200UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Scn8a. The epitope corresponds to the intracellular loop between II and III domains of Scn8a. Does not cross react with any other known proteins. SPECIES REACTIVITIES: It is expected that the antibody will also work on mouse and human due to sequence homology. Other species have not been tested. View All» Immunogen: Peptide corresponding to amino acids 1042-1061 from mouse (Accession number AAD20438) or rat (Accession number AAC26014) Scn8a. View All» Background Information: Voltage-gated sodium channels perform critical roles for electrical signaling in the nervous ssystem by generating action potentials in axons and dndrites. At least 10 genes encode sodium channels in mammals, but specific physiological roles that distinguish each of these isoforms are not well known. Nav1.6 is highly concentrated at nodes of Ranvier of both sensory and motor axons in the peripheral nervous system and at nodes in the central nervous system. Because of its consistant and restrictied labeling, Anti-Nav1.6 (AB5580) has been used effectively as a nodes of Ranvier marker. View All» Species Reactivity:

• Mouse

• Rat
  View All» Application Notes: Western blot: 3.0 μg/mL (1:200) using ECL on rat brain membranes. Immunohistochemistry on fixed frozen sections. Immunocytochemistry on rat dorsal root ganglion primary culture (1:100)Dilutions should be made using a carrier protein such as BSA (1-3%) Optimal working dilutions must be determined by the end user. View All» Control: CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized peptide). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9UQD0 View All» Entrez Gene Number: NM_014191.2 View All» Gene Symbol:
  • SCN8A

  • Nav1.6

  • MED

  • NaCh6

  • PN4

  • CerIII
    View All» Alternate Names: Sodium Channel Nav1.6; NaCh6; PN4; CerIII View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: Q9UQD0 # Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.SIZE: 1980 amino acids; 225280 Da SUBUNIT: Interacts with NEDD4 and NEDD4L (By similarity).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.DOMAIN: SwissProt: Q9UQD0 The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.PTM: May be ubiquitinated by NEDD4L; which would promote its endocytosis (By similarity).SIMILARITY: Belongs to the sodium channel family. & Contains 1 IQ domain. View All» Brand Family: Chemicon View All» Product Name: Anti-SCN8A Sodium Channel Antibody | AB5580-200UL View All» Concentration: 120 μg/200 μL (0.8 mg/mL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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