货号：AB5599

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Potassium Channel KCNQ5 Antibody | AB5599 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Specific for KCNQ5. View All» Immunogen: Fusion protein from KCNQ5 View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1:500-1:2,000. Suggested blocking buffer is 5% non-fat dry milk with 0.05% Tween 20 in PBS. Expected molecular weight is approximately 116 kDa on transfected cells. On rat brain extract the antibody recognizes a protein of approximately 141 kDa. Immunohistochemistry: 1:1,000 for 24-72 hours on 4% paraformaldehyde fixed human tissue. Suggested blocking buffer 3% goat serum, 1% BSA, 0.25% Triton X100 in PBS. Immunocytochemistry: 1:1,000 on transfected HEK293 cell line. Suggested fixative is 4% paraformaldehyde in PBS. Suggested blocking buffer 3% goat serum, 1% BSA, 0.25% Triton X100 in PBS. Immunoprecipitation Optimal working dilutions must be determined by the end user. View All» Presentation: Rabbit serum. Liquid. View All» Storage Conditions: Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer. View All» UniProt Number: Q9NR82 View All» Entrez Gene Number: NM_019842.2 View All» Gene Symbol:
  • KCNQ5

  • OTTHUMP00000064153

  • Kv7.5

  • OTTHUMP00000064152
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of only one has been determined. View All» UniProt Summary: FUNCTION: SwissProt: Q9NR82 # Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of an heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors.SIZE: 932 amino acids; 102179 Da SUBUNIT: Heteromultimer with KCNQ3.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.DOMAIN:SwissProt: Q9NR82 The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity).SIMILARITY: Belongs to the potassium channel family. KQT subfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-Potassium Channel KCNQ5 Antibody | AB5599 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
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