货号：AB5601

品牌：Merck Millipore

规格：

目录价：￥3908.00

市场价格：￥3321.80

会员价格：￥3126.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RAGE Antibody, C-terminus | AB5601 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Specific for Receptor of Advanced Glycosylated End Products (RAGE). This antibody immunolabels vessels from diabetic tissues in formalin-fixed paraffin sections. View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide from the C-terminus of human RAGE, amino acids 385 to 399. {RAELNQSEEPEAGES}. View All» Background Information: RAGE is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation, and are know as advanced glycation end products (AGEs). It is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity.The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune/inflammatory reactions of the vessel walls. In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE. This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics. In the brain, RAGE also binds amyloid beta (Ab). Because Ab is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE. The RAGE-Ab interaction is thought to result in oxidative stress leading to neuronal degeneration. View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry: > 1:200 on paraffin embedded tissue sections. The antibody reacts well with human diabetic kidney. The antibody may show better reactivity after performing antigen retrieval by the citrate buffer/pressure cooker method. ELISA: > 1:5,000 Optimal working dilutions must be determined by the end user. View All» Presentation: Goat serum. Liquid. Containing 0.01% thimerosal. View All» Storage Conditions: Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap. View All» UniProt Number: Q9UQ07 View All» Entrez Gene Number: NM_014226.1 View All» Gene Symbol:

• RAGE

• RAGE-1

• RAGE1

• MOK

• EC 2.7.11.22
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Immunohistochemistry
    View All» UniProt Summary: FUNCTION: SwissProt: Q9UQ07 # Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (By similarity).SIZE: 419 amino acids; 48014 Da SUBCELLULAR LOCATION: Cytoplasm (By similarity).TISSUE SPECIFICITY: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.PTM: Autophosphorylated (By similarity).SIMILARITY: SwissProt: Q9UQ07 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain. View All» Brand Family: Chemicon View All» Product Name: Anti-RAGE Antibody, C-terminus | AB5601 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Serum View All» Host: Goat View All»
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