货号：AB5660P

品牌：Merck Millipore

规格：

目录价：￥3779.00

市场价格：￥3212.15

会员价格：￥3023.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Histamine Receptor 3, C-terminus View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes rat Histamine Receptor 3 (HR3). The immunogen shows no significant sequence homology with other histamine receptors. SPECIES REACTIVITIES: The immunogen peptide is 88% conserved in chicken and 83% in human. 100% with mouse (gi22137512). Reactivity with other species has not been confirmed. View All» Epitope: C-terminus View All» Immunogen: An 18 amino acid peptide sequence within the cytoplasmic, C-terminus of rat HR3 (Lovenberg et al. 1999, 2000). {CPQ KLK VQP HGS LEQ CWK} (Rat 428-445aa) View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1-10 μg/mL using ECL. ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in 100mM Tris, pH 7.5, containing 0.2% BSA and 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9Y5N1 View All» Entrez Gene Number: NM_007232.1 View All» Gene Symbol:

• HRH3

• GPCR97

• HH3R
  View All» Alternate Names: H3R View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H3 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. View All» UniProt Summary: FUNCTION: SwissProt: Q9Y5N1 # The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 niether modified adenylate cyclase activity nor induced intracellular calcium mobilization.SIZE: 445 amino acids; 48671 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.SIMILARITY: SwissProt: Q9Y5N1 ## Belongs to the G-protein coupled receptor 1 family. MISCELLANEOUS: Does not bind to cimetidine and tripolidine. Shows modest affinity for thioperamide, imetit, N-alpha-methylhistamine and R(-)-alpha-methylhistamine. Isoform 4 is unable to bind to iodoproxyfan while isoforms 1 and 3 bind it with high affinity." View All» Brand Family: Chemicon View All» Product Name: Anti-Histamine Receptor 3, C-terminus View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-158129.htm
    © Merck Millipore代理AB5660P Rb X HR3，产品报价联系微信jinshanbio