货号：AB5666P

品牌：Merck Millipore

规格：50MIG

目录价：￥5047.00

市场价格：￥4289.95

会员价格：￥4037.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neurite Outgrowth Inhibitor A/B/C Antibody | AB5666P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human Neurite Outgrowth Inhibitor Protein A/B/C (Nogo-A/B/C). The immunogen peptide is within the 25 amino acid region identified for the inhibition of neurite outgrowth (Chen et al. 2000; GrandPre et al. 2000; Goldberg & Barres 2000; Prinijha et al. 2000; Tessier-Lavigne & Goodman 2000; Nagase et al. 1998).The immunogen shows no significant sequence homology with other known proteins. SPECIES REACTIVITIES: The immunogen peptide is 92% conserved in rat Nogo or rat foocen-m1.2 protein (Chen et al. 2000; GrandPre et al. 2000; Goldberg & Barres 2000; Prinijha et al. 2000; Tessier-Lavigne & Goodman 2000; Nagase et al. 1998). Reactivity with other species has not been confirmed. View All» Immunogen: A 13 amino acid peptide between the putative 2nd-3rd transmembrane domain of human Nogo-A (Chen et al. 2000; GrandPre et al. 2000; Goldberg & Barres 2000; Prinijha et al. 2000; Tessier-Lavigne & Goodman 2000; Nagase et al. 1998). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Western blot: 1-10 μg/mL using ECL. The calculated molecular weight of Nogo-A is approximately 135 kDa. However a molecular weight of approximately 180 kDa has been reported for full length Nogo-A (Chen et al. 2000; GrandPre et al. 2000; Goldberg & Barres 2000; Prinijha et al. 2000; Tessier-Lavigne & Goodman 2000; Nagase et al. 1998). ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well. Optimal working dilutions must be determined by the end user. View All» Presentation: Liquid in PBS containing 0.1% BSA and 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9NQC3 View All» Entrez Gene Number:
  • NM_007008.2

  • NM_020532.4

  • NM_153828.2

  • NM_207520.1

  • NM_207521.1
    View All» Gene Symbol:
    • RTN4

    • RTN4-B1

    • Nbla10545

    • RTN-X

    • reticulon-4A

    • Nogo-C

    • NSP

    • RTN-x

    • ASY

    • foocen

    • NSP-CL

    • NOGOC

    • RTN4-A

    • Reticulon-4

    • Nbla00271

    • KIAA0886

    • NOGOA

    • Reticulon-5

    • Foocen

    • NI220/250

    • RTN4-C

    • RTN4-B2

    • SP1507

    • NOGO-A

    • NOGO

    • NOGOB

    • Nogo-B
      View All» Alternate Names: Nogo-A/B/C View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Western Blotting
        View All» Entrez Gene Summary: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. View All» UniProt Summary: FUNCTION: SwissProt: Q9NQC3 # Potent neurite growth inhibitor in vitro and plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS. Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.SIZE: 1192 amino acids; 129931 Da SUBUNIT: Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3 interact with BACE1 and BACE2.SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.TISSUE SPECIFICITY: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis- specific.DOMAIN: SwissProt: Q9NQC3 Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo- 66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).SIMILARITY: Contains 1 reticulon domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Neurite Outgrowth Inhibitor A/B/C Antibody | AB5666P View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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