货号：AB5675

品牌：Merck Millipore

规格：50Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Metabotropic Glutamate Receptor 5 Antibody, pain | AB5675 View All» Replaces: AB1596, 06-451 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes mGluR5. View All» Molecular Weight: 132 kDa View All» Immunogen: Synthetic peptide from rat mGluR5. View All» Species Reactivity: Rat View All» Application Notes: Western blot: 0.1-0.5 μg/mL using ECL on rat brain microsomal preparation. Reacts with a band of ~132 kDa. Immunohistochemistry: 0.1-0.2 μg/mL on rat brain and mouse brain sections fixed with 4% paraformaldehyde containing 15% saturated picric acid in 0.1M PB, pH 7.4. Optimal working dilutions must be determined by the end user. View All» Control: Brain tissue View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity Purified immunoglobulin. Liquid in 0.02 M Phosphate buffer, 0.2 M NaCl, pH 7.6, containing 0.1 % sodium azide. View All» Storage Conditions: Maintain material at 2–8°C for up to 6 months after date of receipt. View All» UniProt Number: P31424 View All» Entrez Gene Number: NM_000842.1 View All» Gene Symbol:

• GRM5

• mGluR5

• MGLUR5A

• mGlu5

• MGLUR5

• MGLUR5B

• GPRC1E
  View All» Alternate Names: mGluR5 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunohistochemistry

  • Western Blotting
    View All» Entrez Gene Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: P41594 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current.SIZE: 1212 amino acids; 132469 Da SUBUNIT: The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity).SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.SIMILARITY: SwissProt: P41594 ## Belongs to the G-protein coupled receptor 3 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Metabotropic Glutamate Receptor 5 Antibody, pain | AB5675 View All» Concentration: 0.68 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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