货号：AB5699

品牌：Merck Millipore

规格：100UL

目录价：￥6434.00

市场价格：￥5468.90

会员价格：￥5147.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cysteine-rich Motor Neuron 1 Antibody | AB5699 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Crim1 SUBCELLULAR LOCALIZATION: Intracellular and Membrane associated. View All» Immunogen: Recombinant protein from the cytoplasmic tail of mouse Crim1. View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Western blot: 1:1,000 using ECL. The antibody reacts with proteins of ~120 kDa. Preferred gel percentage is 7.5%. Suggested blocking buffer is PBS containing 5% non-fat milk. Suggested dilution buffer is PBS containing 1% non-fat milk. Immunoprecipitation: 5 μL to 1 mL of cell extract. Preferred tissue/cell lysis buffer is RIPA. Suggested incubation time is 2-4 hours. Suggested capture agent is Protein A. Optimal working dilutions must be determined by the end user. View All» Presentation: Rabbit serum. Liquid. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9NZV1 View All» Entrez Gene Number: NM_016441.1 View All» Gene Symbol:
  • CRIM1

  • CRIM-1

  • MGC138194

  • S52
    View All» Alternate Names: CRIM1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180) families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival (Kolle et al., 2000 [PubMed 10642437]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q9NZV1 # May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.SIZE: 1036 amino acids; 113738 Da SUBUNIT: Interacts with BMP4 and BMP7.SUBCELLULAR LOCATION: Processed cysteine-rich motor neuron 1 protein: Secreted. & Cell membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).PTM: N-glycosylated.SIMILARITY: SwissProt: Q9NZV1 ## Contains 4 antistasin-like domains. & Contains 1 IGFBP N-terminal domain. & Contains 6 VWFC domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Cysteine-rich Motor Neuron 1 Antibody | AB5699 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Cytoplasmic, motor neurons View All» Format: Serum View All» Host: Rabbit View All»
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