货号：AB5725

品牌：Merck Millipore

规格：100Ug

目录价：￥5315.00

市场价格：￥4517.75

会员价格：￥4252.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Gephyrin Antibody | AB5725 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Gephyrin View All» Immunogen: Synthetic peptide from rat gephyrin. View All» Species Reactivity:

• Mouse

• Rat
  View All» Application Notes: Western blot: 0.5-1.0 μg/mL using ECL on mouse cerebellum tissue lysate. The antibody reacts with a protein of ~93 kDa. An additional band of ~35 kDa may also be seen depending on sample used. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid. View All» Storage Conditions: Maintain at +2-8°C in undiluted aliquots for up to 6 months after date of receipt. View All» UniProt Number: Q9NQX3 View All» Entrez Gene Number:
  • NM_001024218.1

  • NM_020806.4
    View All» Gene Symbol:
    • GPHN

    • GPHRYN

    • GPH

    • gephyrin

    • GEPH

    • Gephyrin.

    • KIAA1385
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. View All» UniProt Summary: FUNCTION: SwissProt: Q9NQX3 # Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Involved in molybdenum cofactor biosynthesis. Required for molybdenum transfer to molybdopterin. In a first step, copper-molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released (By similarity).COFACTOR: Magnesium (By similarity).SIZE: 736 amino acids; 79748 Da SUBUNIT: Homotrimer. Interacts with GABARAP (By similarity).DOMAIN:SwissProt: Q9NQX3 Contains 2 functional domains that are expressed as separate proteins in bacteria. The G-domain adenylates molybdopterin. The E-domain inserts molybdenum into adenylated molybdopterin.DISEASE: SwissProt: Q9NQX3 # Defects in GPHN are the cause of molybdenum cofactor deficiency type C (MOCOD type C) [MIM:252150]. MOCOD type C is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death.SIMILARITY: In the N-terminal section; belongs to the moaB/mog family. & In the C-terminal section; belongs to the moeA family. View All» Brand Family: Chemicon View All» Product Name: Anti-Gephyrin Antibody | AB5725 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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