货号：AB5755

品牌：Merck Millipore

规格：100Ug

目录价：￥4131.00

市场价格：￥3511.35

会员价格：￥3304.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Glial Derived Neurotrophic Factor Antibody | AB5755 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Glial Derived Neurotrophic Factor (GDNF). View All» Immunogen: Synthetic peptides from human GDNF. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Immunoblotting: 1:500-1:2,000 Immunohistochemistry: not tested. It is recommended that you try the antibody at 1:50-1:500. ELISA: 1:500-1:2,000 Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P39905 View All» Entrez Gene Number:
  • NM_000514.2

  • NM_199231.1

  • NM_199234.1
    View All» Gene Symbol:
    • GDNF

    • HFB1-GDNF

    • ATF1

    • ATF2

    • hGDNF

    • ATF
      View All» Alternate Names: GDNF View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Western Blotting
        View All» Entrez Gene Summary: This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease. View All» UniProt Summary: FUNCTION: SwissProt: P39905 # Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.SIZE: 211 amino acids; 23720 Da SUBUNIT: Homodimer; disulfide-linked.SUBCELLULAR LOCATION: Secreted.TISSUE SPECIFICITY: In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen.DISEASE: SwissProt: P39905 # Defects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. & Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.SIMILARITY: SwissProt: P39905 ## Belongs to the TGF-beta family. GDNF subfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-Glial Derived Neurotrophic Factor Antibody | AB5755 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Chicken View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://www.16ao.com/thread-158179.htm
        © Merck Millipore代理AB5755 Anti-Glial Derived Neurotrophic Factor Antibody;store at -20℃，产品报价联系微信jinshanbio