货号：AB5789

品牌：Merck Millipore

规格：

目录价：￥4551.00

市场价格：￥3868.35

会员价格：￥3640.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calcium Channel Antibody, β 4 | AB5789 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: beta4 calcium channel (Voltage-Dependant L-type Calcium Channel, beta4 subunit). View All» Immunogen: Synthetic peptide from rat beta4 calcium channel. View All» Species Reactivity: Human View All» Application Notes: Immunoblotting: 5-10 μg/mL. Reacts with the 55 kD protein. Optimal working dilutions must be determined by the end user. View All» Presentation: Purified immunoglobulin. Liquid in PBS containing 0.08% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O00305 View All» Entrez Gene Number:

• NM_000726.2

• NM_001005746.1

• NM_001005747.1
  View All» Gene Symbol:
  • CACNB4

  • EA5

  • CACNLB4

  • CAB4

  • EJM
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. View All» UniProt Summary: FUNCTION: SwissProt: O00305 # The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.SIZE: 520 amino acids; 58169 Da SUBUNIT: The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma.TISSUE SPECIFICITY: Expressed predominantly in the cerebellum and kidney.DISEASE: SwissProt: O00305 # Defects in CACNB4 are a cause of idiopathic generalized epilepsy (IGE) [MIM:600669]. IGE is characterized by recurrent generalized seizures. & Defects in CACNB4 are a cause of juvenile myoclonic epilepsy (JME) [MIM:606904]. JME is a common epileptic syndrome characterized by afebrile seizures, onset in adolescence (rather than in childhood) and myoclonic jerks.SIMILARITY: SwissProt: O00305 ## Belongs to the calcium channel beta subunit family. & Contains 1 SH3 domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Calcium Channel Antibody, β 4 | AB5789 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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