货号：AB5840

品牌：Merck Millipore

规格：

目录价：￥4774.00

市场价格：￥4057.90

会员价格：￥3819.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dab1 Antibody | AB5840 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: On western blots of mouse brain extracts, the antibody recognizes a band migrating at approximately 80 kDa corresponding to Dab1. No cross reactivity to human or mouse Dab2. View All» Molecular Weight: 80 kDa View All» Immunogen: Highly purified GST-fusion protein corresponding to residues 400-555 of mouse Dab1. View All» Background Information: Dab1 is a protein arising from the mouse gene dab, that is related to the Drosophila gene 'disabled'. Mutations in the mouse dab gene may result in the 'scrambler' and 'yotari' phenotypes. Dab encodes a phosphoprotein that binds non-receptor tyrosine kinases and has been implicated in neuron development. Dab1 is expressed in neuronal populations exposed to reelin, as determined by in situ hybridization to embryonic mouse brain tissue. Dab1 may function as a signaling molecule that regulates positioning in the developing brain. Cloning of human DAB1 and sequence determinations suggests a 96% homology to the mouse sequence. Very low density lipoprotein receptors (VLDLR) and apolipoprotein E receptor-2 (APOER2) both bind Dab1 on their cytoplasmic tails. Dab1 expression is upregulated in knockout mice lacking both Vldlr and Apoer2 genes. View All» Species Reactivity: Mouse View All» Application Notes: Western blotting: 1:1,000-1:5,000 Immunocytochemistry: 1:500-1:1,000 Immunohistochemistry: 1:5,000-1:20,000 on cryofixed tissues Immunoprecipitation Optimal working dilutions must be determined by the end user. View All» Control: Brain tissue View All» Purification Method: Serum, delipidated and defibrinated View All» Presentation: Delipidated and defibrinated Serum in 0.02M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% sodium azide. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: O75553 View All» Entrez Gene Number: NM_021080.3 View All» Gene Symbol: DAB1 View All» Alternate Names: Disabled homolog 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:

• Immunocytochemistry

• Immunohistochemistry

• Immunoprecipitation

• Western Blotting
  View All» Entrez Gene Summary: The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: O75553 # Adapter molecule functioning in neural development. May regulate SIAH1 activity (By similarity).SIZE: 588 amino acids; 63775 Da SUBUNIT: Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1 (By similarity). Interacts with LRP1.DOMAIN: SwissProt: O75553 The PID domain specifically binds to the Asn-Pro-Xaa- Tyr(P) motif found in many tyrosine-phosphorylated proteins.PTM: Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (By similarity). Also phosphorylated on Ser- 524 independently of reelin signaling (By similarity).SIMILARITY: Contains 1 PID domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Dab1 Antibody | AB5840 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Serum View All» Host: Rabbit View All»
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