货号：AB5852

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SHANK1a Antibody, N-terminus | AB5852 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Shank1a, N-terminal. View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to the N-terminus of rat Shank1a. View All» Background Information: Shank is a novel family of postsynaptic density proteins (PSD) that bind to PDS-95-associated protein GKAP. Its putative function is to act as a scaffold protein in the PSD to cross-link NMDA receptors/PSD-95 complexes and couple them to regulators of the actin cytoskeleton. Shank1a is a splice variant of Shank1. View All» Species Reactivity: Rat View All» Application Notes: Western blotting: 1:500-1:1,000 Optimal working dilutions must be determined by the end user. View All» Presentation: Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9Y566 View All» Entrez Gene Number: NM_016148.2 View All» Gene Symbol:

• SHANK1

• SSTRIP

• SPANK-1

• Shank1

• synamon
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: Q9Y566 # Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.SIZE: 2161 amino acids; 225021 Da SUBUNIT: May homomultimerize via its SAM domain (By similarity). Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 (By similarity). Part of a complex with DLG4/PSD- 95 and DLGAP1/GKAP (By similarity). Interacts with BAIAP2.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density of neuronal cells (By similarity).TISSUE SPECIFICITY: Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.SIMILARITY: SwissProt: Q9Y566 ## Belongs to the SHANK family. & Contains 6 ANK repeats. & Contains 1 PDZ (DHR) domain. & Contains 1 SAM (sterile alpha motif) domain. & Contains 1 SH3 domain. View All» Brand Family: Chemicon View All» Product Name: Anti-SHANK1a Antibody, N-terminus | AB5852 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Target / Localization: Postsynaptic View All» Format: Purified View All» Host: Rabbit View All»
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