货号：AB5886-50UL

品牌：Merck Millipore

规格：1EA

目录价：￥4754.67

市场价格：￥4041.47

会员价格：￥3803.74

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Caspr2 Antibody | AB5886-50UL View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Caspr2 (Contactin-Associated Protein 2). The epitope does not share homology with any other known proteins. SPECIES REACTIVITIES: It is expected that the antibody will also react with mouse due to identical sequence homology. Other species have not been tested. View All» Immunogen: Synthetic peptide corresponding amino acids 1315-1331 of human Caspr2 (Accession number NP 054860). View All» Species Reactivity: Rat View All» Application Notes: Western blot: 1:1,000 using ECL on rat brain membranes. Dilutions should be made using a carrier protein such as BSA (1-3%) Optimal working dilutions must be determined by the end user. View All» Control: CONTROL ANTIGEN: Included free of charge with the antibody is 20 μg of control antigen. The stock solution of the antigen can be made up using 100 μL of sterile distilled water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user. View All» Presentation: Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, 5% sucrose as a stabilizer and 0.025% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for View All» Storage Conditions: Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q9UHC6 View All» Entrez Gene Number: NM_014141.4 View All» Gene Symbol:

• CNTNAP2

• DKFZp781D1846

• CASPR2

• KIAA0868

• Caspr2

• NRXN4

• CDFE
  View All» Alternate Names: Contactin-Associated Protein-like 2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons and associated with potassium channels. It may play a role in the local differentiation of the axon into distinct functional subdomains. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It may represent a positional candidate gene for the DFNB13 form of nonsyndromic deafness. View All» UniProt Summary: FUNCTION: SwissProt: Q9UHC6 # May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction.SIZE: 1331 amino acids; 148167 Da SUBUNIT: Associates with KCNA2 (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).TISSUE SPECIFICITY: Predominantly expressed in nervous system.DISEASE: SwissProt: Q9UHC6 # Defects in CNTNAP2 are the cause of cortical dysplasia- focal epilepsy syndrome (CDFE syndrome) [MIM:610042]. Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop.SIMILARITY: SwissProt: Q9UHC6 ## Belongs to the neurexin family. & Contains 2 EGF-like domains. & Contains 1 F5/8 type C domain. & Contains 4 laminin G-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-Caspr2 Antibody | AB5886-50UL View All» Concentration: 0.3 mg/mL (after reconstitution) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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