货号：AB5887P

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Myosin V Antibody | AB5887P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Myosin V. By Western blot the antibody reacts with the 196 kDa myosin V protein of squid. Cross reactivity with chicken and mouse as well, other species not tested. View All» Immunogen: Synthetic peptide cooresponding to amino acids 1743-1758 of the squid myosin V gene (AAF12809). View All» Species Reactivity:

• Chicken

• Mouse

• Squid
  View All» Application Notes: Western blot: 1-5 μg/mL. Single band, migrating at ~200kDa in squid lysates. Optimal working dilutions must be determined by the end user. View All» Presentation: Affinity purified immunoglobulin. Liquid in 0.02M PBS containing 0.25M NaCl, pH 7.6 with 0.1% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap. View All» UniProt Number: Q9Y4I1 View All» Entrez Gene Number: NM_000259.2 View All» Gene Symbol:
  • MYO5A

  • GS1

  • Myosin-Va

  • myoxin

  • MYR12

  • dilute

  • Myoxin

  • Myosin-12

  • MYO5

  • MYH12
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: Q9Y4I1 # Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. May also be required for some polarization process involved in dendrite formation.SIZE: 1855 amino acids; 215421 Da SUBUNIT: May be a homodimer, which associates with multiple calmodulin or myosin light chains. Binds MLPH and MYRIP (By similarity).TISSUE SPECIFICITY: Detected in melanocytes.DISEASE: SwissProt: Q9Y4I1 # Defects in MYO5A are a cause of Griscelli syndrome type-1 (GS1) [MIM:214450]; also known as Griscelli syndrome with primary neurologic impairment. Griscelli syndrome is a rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, silvery-gray hair and accumulation of melanosomes in melanocytes. GS1 patients show developmental delay, hypotonia and mental retardation, without apparent immune abnormalities. & Defects in MYO5A are a cause of Griscelli syndrome type-3 (GS3) [MIM:609227]. GS3 is characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, silvery-gray hair and accumulation of melanosomes in melanocytes, without other clinical manifestations. & Defects in MYO5A are a cause of Elejalde syndrome [MIM:256710]; also known as neuroectodermal melanolysosomal disease. Elejalde syndrome is an autosomal recessive condition characterized by skin hypopigmentation, the presence of large clumps of pigment in hair shafts, silvery-gray hair, accumulation of melanosomes in melanocytes and primary neurological abnormalities. Elejalde syndrome may be the same entity as Griscelli syndrome type I.SIMILARITY: SwissProt: Q9Y4I1 ## Contains 1 dilute domain. & Contains 6 IQ domains. & Contains 1 myosin head-like domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Myosin V Antibody | AB5887P View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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