货号：AB5898

品牌：Merck Millipore

规格：50UL

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Protein Gene Product 9.5 Antibody | AB5898 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes Protein Gene Product 9.5 (PGP9.5). View All» Immunogen: A 17 amino acid peptide corresponding to amino acids 175-191 from soluble cytoplasmic human PGP9.5. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Immunohistochemistry: 1:500. Optimal working dilutions must be determined by end user. blocking buffer for 1 hour at room temperature. Primary antibody was diluted in blocking buffer to the appropriate working dilution. Blocking buffer was removed and the slides were then incubated at 4°C for 18-24 hours with AB5898 (1:500). After rinsing in PBS 3 times sections were incubated for 60 minutes at room temperature with Cy3-conjugated secondary antibodies. After mounting in a mixture of PBS and glycerol (1:3) containing 0.1% p-phenylenediamine, sections were examined with a Nikon Microphot-SA epifluorescence microscope. View All» Control: Brain tissue View All» Purification Method: Unpurified View All» Presentation: Liquid. Contains 0.05% sodium azide. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P09936 View All» Entrez Gene Number: NM_004181.3 View All» Gene Symbol:
  • UCHL1

  • PARK5

  • UCH-L1

  • Uch-L1

  • PGP9.5

  • EC 3.4.19.12

  • EC 6.-.-.-
    View All» Alternate Names: PGP 9.5; UCH-L1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» Entrez Gene Summary: UCHL1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons (Doran et al., 1983 [PubMed 6343558]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P09936 # Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.SIZE: 223 amino acids; 24824 Da SUBUNIT: Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary.PTM: O-glycosylated (By similarity).DISEASE: SwissProt: P09936 # Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. In AD, UCHL1 was found to be associated with neurofibrillary tangles.SIMILARITY: SwissProt: P09936 ## Belongs to the peptidase C12 family.MISCELLANEOUS: In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8. View All» Brand Family: Chemicon View All» Product Name: Anti-Protein Gene Product 9.5 Antibody | AB5898 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μL View All» Target / Localization: All neurons, neuroendocrine cells View All» Format: Serum View All» Host: Guinea Pig View All»
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